ITEM METADATA RECORD
Title: Concordance Among Pathologists in the Second Cardiac Allograft Rejection Gene Expression Observational Study (CARGO II)
Authors: Crespo-Leiro, Maria G ×
Zuckermann, Andreas
Bara, Christoph
Mohacsi, Paul
Schulz, Uwe
Boyle, Andrew
Ross, Heather J
Parameshwar, Jayan
Zakliczynski, Michael
Fiocchi, Roberto
Stypmann, Joerg
Hoefer, Daniel
Lehmkuhl, Hans
Deng, Mario C
Leprince, Pascal
Berry, Gerald
Marboe, Charles C
Stewart, Susan
Tazelaar, Henry D
Baron, Helen M
Coleman, Ian-Charles
Vanhaecke, Johan #
Issue Date: 2012
Publisher: Lippincott Williams & Wilkins
Series Title: Transplantation vol:94 issue:11 pages:1172-1177
Abstract: BACKGROUND:
There has been no large evaluation of the ISHLT 2004 acute cellular rejection grading scheme for heart graft endomyocardial biopsy specimens (EMBs).
METHODS:
We evaluated agreement within the CARGO II pathology panel and between the panel (acting by majority) and the collaborating centers (treated as a single entity), regarding the ISHLT grades of 937 EMBs (with all grades ≥2R merged because of small numbers).
RESULTS:
Overall all-grade agreement was almost 71% both within the panel and between the panel and the collaborating centers but, in both cases, was largely because of agreement on grade 0: for the average pair of pathologists, fewer than a third of the EMBs assigned grade ≥2R by at least one were assigned this grade by both.
CONCLUSION:
The 2004 revision has done little to improve agreement on the higher ISHLT grades. An EMB grade ≥2R is not by itself sufficient as a basis for clinical decisions or as a research criterion. Steps should be taken toward greater uniformity in EMB grading, and efforts should be made to replace the ISHLT classification with diagnostic criteria--EMB based or otherwise--that correspond better with the pathophysiology of the transplanted heart.
ISSN: 0041-1337
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Abstract Transplantation 2012 94 1172.docx Published 14KbMicrosoft WordView/Open

 


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science