Author:

Keywords:

ERP, MMN, P300, Novelty detection, Audition, Perception, Science & Technology, Social Sciences, Life Sciences & Biomedicine, Behavioral Sciences, Neurosciences, Psychology, Experimental, Neurosciences & Neurology, Psychology, EVENT-RELATED POTENTIALS, MISMATCH NEGATIVITY MMN, EVOKED-POTENTIALS, STIMULUS DEVIANCE, ODDBALL, GENERATORS, RESPONSES, CORTEX, FMRI, Acoustic Stimulation, Adolescent, Adult, Brain, Brain Mapping, Contingent Negative Variation, Electroencephalography, Evoked Potentials, Auditory, Female, Humans, Male, Reaction Time, Regression Analysis, Signal Detection, Psychological, Sleep Deprivation, Time Factors, Young Adult, 1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences, Experimental Psychology, 3209 Neurosciences, 5202 Biological psychology, 5204 Cognitive and computational psychology

Abstract:

Auditory novelty detection can be fractionated into multiple cognitive processes associated with their respective neurophysiological signatures. In the present study we used high-density scalp event-related potentials (ERPs) during an active version of the auditory oddball paradigm to explore the lifetimes of these processes by varying the stimulus onset asynchrony (SOA). We observed that early MMN (90-160 ms) decreased when the SOA increased, confirming the evanescence of this echoic memory system. Subsequent neural events including late MMN (160-220 ms) and P3a/P3b components of the P3 complex (240-500 ms) did not decay with SOA, but showed a systematic delay effect supporting a two-stage model of accumulation of evidence. On the basis of these observations, we propose a distinction within the MMN complex of two distinct events: (1) an early, pre-attentive and fast-decaying MMN associated with generators located within superior temporal gyri (STG) and frontal cortex, and (2) a late MMN more resistant to SOA, corresponding to the activation of a distributed cortical network including fronto-parietal regions.