Title: Dipeptides as leaving group in the enzyme-catalyzed DNA synthesis
Authors: Song, Xiao-Ping
Bouillon, Camille
Lescrinier, Eveline
Herdewijn, Piet # ×
Issue Date: Dec-2012
Publisher: Verlag Helvetica Chimica Acta
Series Title: Chemistry & Biodiversity vol:9 issue:12 pages:2685-2700
Article number: 10.1002/cbdv.201200261
Abstract: Conjugates of 2'-deoxyadenosine monophosphate with dipeptides have been synthesized and tested as substrates for several polymerases. Although the incorporation efficiency is not very high, it demonstrates that some of these dipeptides can be accommodated in the active site of polymerases and function as leaving groups in the enzymatic synthesis of DNA.
ISSN: 1612-1872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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