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Title: Cognitive aspects of freezing of gait in Parkinson's disease: a challenge for rehabilitation
Authors: Heremans, Elke ×
Nieuwboer, Alice
Spildooren, Joke
Vandenbossche, J
Deroost, N
Soetens, Erwin
Kerckhofs, Eric
Vercruysse, Sarah #
Issue Date: Jan-2013
Publisher: Springer-Verlag
Series Title: Journal of Neural Transmission vol:120 issue:4 pages:543-557
Abstract: Freezing of gait (FOG) is a very disabling symptom affecting up to half of the patients with Parkinson's disease (PD). Evidence is accumulating that FOG is caused by a complex interplay between motor, cognitive and affective factors, rather than being a pure motor phenomenon. In the current paper, we review the evidence on the specific role of cognitive factors in FOG. Results from behavioral studies show that patients with FOG experience impairments in executive functioning and response selection which predict that motor learning may be compromised. Brain imaging studies strengthen the neural basis of a potential association between FOG and cognitive impairment, but do not clarify whether it is a primary or secondary determinant of FOG. A FOG-related reduction of cognitive resources implies that adaptation of rehabilitation interventions is indicated for patients with FOG to promote the consolidation of learning.
URI: 
ISSN: 0300-9564
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group for Neuromotor Rehabilitation
× corresponding author
# (joint) last author

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