Title: Contractions, a risk for premature rupture of fetal membranes: A new protocol with cyclic biaxial tension
Authors: Perrini, Michela ×
Bürzle, Wilfried
Haller, Claudia
Ochsenbein-Kölble, Nicole
Deprest, Jan
Zimmermann, Roland
Mazza, Edoardo
Ehrbar, Martin #
Issue Date: Sep-2013
Publisher: Butterworth-Heinemann
Series Title: Medical Engineering & Physics vol:35 issue:6 pages:846-851
Article number: S1350-4533(12)00241-X
Abstract: This study aims at investigating the effect of repeated mechanical loading on the rupture and deformation properties of fetal membranes. Ten membranes delivered by cesarean sections were tested using a custom-built inflation device which provides a multi-axial stress state. For each membrane, a group of samples was first cyclically stretched by application of pressure ranging between 10 and 40mmHg. After cycles, samples were subjected to inflation up to rupture. Differences between mechanical parameters from cycled and uncycled samples were analyzed. Ten cycles at 40% of mean critical membrane tension-representative of mean physiologic contractions-did not affect strength and stiffness of fetal membranes but reduced the work to rupture, thus indicating that contractions might increase the risk of premature rupture of the membrane. Cyclic testing demonstrated a large hysteresis loop and irreversible deformation on the first cycle, followed by rapid stabilization on subsequent cycles. In 80% of tests, amnion ruptured first and at the periphery of the sample, under uniaxial strain state. Chorion ruptured at higher deformation levels in the middle, under biaxial strain state.
ISSN: 1350-4533
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science