Title: Interleukin-6 (IL-6) production in mice infected with Trypanosoma cruzi - effect of its paradoxical increase by anti-IL-6 monoclonal antibody treatment on infection and acute-phase and humoral immune responses
Authors: Truyens, C ×
Angelo-Barrios, A
Torrico, F
Van Damme, Jozef
Heremans, Hubertine
Carlier, Y #
Issue Date: Feb-1994
Publisher: Amer soc microbiology
Series Title: Infection and immunity vol:62 issue:2 pages:692-6
Abstract: Trypanosoma cruzi infection of mice triggered endogenous production of interleukin-6 (IL-6) during the ascending phase of parasitemia. Injections of anti-IL-6 monoclonal antibody in infected mice at the time of the serum IL-6 peak paradoxically increased IL-6 levels to 60- to 80-fold those in infected mice receiving unrelated immunoglobulins. This early and transient increase in circulating IL-6 levels modified neither the immunoglobulin nor T. cruzi-specific antibody levels of immunoglobulin G1 (IgG1), IgG2a, IgG2b, IgG3, IgM, IgA, and IgE isotypes or the final outcome of infection nor the blood or tissular parasite levels. However, it tended to delay mortality of mite and to increase the levels of the acute-phase protein serum amyloid P component.
ISSN: 0019-9567
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Immunobiology (Rega Institute)
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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