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Title: Lenalidomide, melphalan, and prednisone followed by lenalidomide maintenance improves health-related quality of life in newly diagnosed multiple myeloma patients aged 65 years or older: results of a randomized phase III trial
Authors: Dimopoulos, Meletios A ×
Delforge, Michel
Hajek, Roman
Kropff, Martin
Petrucci, Maria T
Lewis, Philip
Nixon, Annabel
Zhang, Jingshan
Mei, Jay
Palumbo, Antonio #
Issue Date: May-2013
Publisher: Il Pensiero Scientifico
Series Title: Haematologica vol:98 issue:5 pages:784-788
Abstract: The MM-015 trial assessed lenalidomide-based therapy on health-related quality of life. Patients (n=459) with newly diagnosed multiple myeloma aged ≥65 years were randomized 1:1:1 to nine 4-week cycles of lenalidomide, melphalan, and prednisone, followed by lenalidomide maintenance; or lenalidomide, melphalan, and prednisone, or melphalan and prednisone, with no maintenance therapy. Patients completed health-related quality of life questionnaires at baseline, after every third treatment cycle, and treatment end. Health-related quality of life improved in all treatment groups during induction therapy. Patients receiving lenalidomide maintenance had the most pronounced improvements (Global Health Status/ Quality of Life [P<0.05], Physical Functioning [P<0.01], and Side Effects of Treatment [P<0.05] out of six pre-selected health-related quality of life domains). More patients receiving lenalidomide maintenance achieved minimally important differences (P<0.05 for Physical Functioning). Therefore, lenalidomide, melphalan, and prednisone, followed by lenalidomide maintenance improves health-related quality of life in patients with newly diagnosed multiple myeloma. Clinicaltrials.gov identifier NCT00405756. Keywords: Health-related quality of life, multiple myeloma, lenalidomide, QLQ-C30, QLQ-MY20.
ISSN: 0390-6078
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cell and Gene Therapy Applications (-)
× corresponding author
# (joint) last author

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