Title: Monocyte chemotactic protein-1 is released during lethal and sublethal bacteremia in baboons
Authors: Jansen, P M ×
Van Damme, Jozef
Put, W
Dejong, I W
Taylor, F B
Hack, C E #
Issue Date: 1995
Publisher: Univ chicago press
Series Title: The Journal of Infectious Diseases vol:171 issue:6 pages:1640-2
Abstract: The chemokine monocyte chemotactic protein 1 (MCP-1) is a cytokine with chemotactic activity specific for mononuclear phagocytes. To investigate the possible involvement of MCP-1 in the pathogenesis of sepsis, its course was studied in baboons challenged intravenously with a sublethal or lethal dose of Escherichia coli. Levels of MCP-1 started to increase in both groups of animals 2 h after injection of E. coli, reaching peak levels 4 and 6 h after a sublethal (186 +/- 21 ng/mL) or a lethal (213 +/- 24 ng/mL) dose, respectively. Levels of MCP-1 correlated significantly with plasma levels of another chemokine, interleukin-8 (IL-8; r = .826, P < .001), suggesting that common stimuli mediate the release of both cytokines in this model.
ISSN: 0022-1899
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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