Title: Sildenafil citrate therapy for pulmonary arterial hypertension
Authors: Galiè, Nazzareno ×
Ghofrani, Hossein A
Torbicki, Adam
Barst, Robyn J
Rubin, Lewis J
Badesch, David
Fleming, Thomas
Parpia, Tamiza
Burgess, Gary
Branzi, Angelo
Grimminger, Friedrich
Kurzyna, Marcin
Simonneau, Gérald
Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group #
Contributors: Delcroix, Marion
Issue Date: Nov-2005
Series Title: New England Journal of Medicine vol:353 issue:20 pages:2148-2157
Abstract: Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby enhancing the cyclic guanosine monophosphate-mediated relaxation and growth inhibition of vascular smooth-muscle cells, including those in the lung.
ISSN: 0028-4793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
× corresponding author
# (joint) last author

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