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Title: The odd-skipped related genes Osr1 and Osr2 are induced by 1,25-dihydroxyvitamin D(3)
Authors: Verlinden, Lieve
Kriebitzsch, Carsten
Eelen, Guy
Van Camp, Mark
Leyssens, Carlien
Tan, Biauw Keng
Beullens, Ine
Verstuyf, Annemieke # ×
Issue Date: Jul-2013
Publisher: Pergamon Press
Series Title: Journal of Steroid Biochemistry and Molecular Biology vol:136 pages:94-7
Article number: S0960-0760(12)00253-1
Abstract: The odd-skipped related genes Osr1 and Osr2 encode closely related zinc finger containing transcription factors that are expressed in developing limb. However, their role in osteoblast proliferation and differentiation remains controversial and little is known about their regulation. In this study we showed that both Osr1 and Osr2 were expressed in several murine and human osteoblast cell lines as well as in primary osteoblast cultures. Moreover, their transcript levels were regulated by a number of osteogenic stimuli in murine pre-osteoblast MC3T3-E1 cells. The most robust regulation of Osr1 and Osr2 mRNA levels was observed after stimulation with 1,25-dihydroxyvitamin D(3). 1,25-Dihydroxyvitamin D(3) induced transcript levels of Osr1 and Osr2 and this up-regulation was confirmed in other osteoblast cultures, both from murine and human origin. This article is part of a Special Issue entitled 'Vitamin D Workshop'.
ISSN: 0960-0760
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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