Title: Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues
Authors: Nelissen, Joke
Nuyts, Koen
De Zotti, Marta
Lavigne, Rob
Lamberigts, Chris
De Borggraeve, Wim M # ×
Issue Date: 2012
Publisher: Public Library of Sciene
Series Title: PLoS One vol:7 issue:12
Article number: e51708
Abstract: The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tested for their membrane perturbation properties by fluorescent dye leakage assay and for their antibacterial activity.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Division of Gene Technology (-)
× corresponding author
# (joint) last author

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