Title: Gait characteristics and lower limb muscle strength in women with early and established knee osteoarthritis
Authors: Baert, Isabel
Jonkers, Ilse
Staes, Filip
Luyten, Frank
Truijen, Steven
Verschueren, Sabine # ×
Issue Date: Jan-2013
Publisher: J. Wright
Series Title: Clinical Biomechanics vol:28 issue:1 pages:40-47
Article number: 10.1016/j.clinbiomech.2012.10.007
Abstract: BACKGROUND: Based on novel classification criteria using magnetic resonance imaging, a subpopulation of "early knee osteoarthritis patients" was clearly defined recently. This study assessed whether these early osteoarthritis patients already exhibit gait adaptations (knee joint loading in particular) and changes in muscle strength compared to control subjects and established knee osteoarthritis patients. METHODS: Fourteen female patients with early knee joint degeneration, defined by magnetic resonance imaging (early osteoarthritis), 12 female patients with established osteoarthritis and 14 female control subjects participated. Specific gait parameters and lower limb muscle strength were analyzed and compared between groups. Within the osteoarthritis groups, association between muscle strength and dynamic knee joint loading was also evaluated. FINDINGS: Early osteoarthritis patients presented no altered gait pattern, no significant increase in knee joint loading and no significant decrease in hamstring muscle strength compared to controls, while established osteoarthritis patients did. In contrast, early osteoarthritis patients experienced significant quadriceps weakness, comparable to established osteoarthritis patients. Within the osteoarthritis groups, muscle strength was not correlated with knee joint loading during gait. INTERPRETATION: The results suggest that gait changes reflect mechanical overload and are most likely the consequence of structural degeneration in knee osteoarthritis. Quadriceps weakness might however contribute to the onset and progression of the disease. This study supports the relevance of classification of early osteoarthritis patients and assists in identifying their functional characteristics. This helps to understand the trajectory of disease onset and progression and further develop more targeted strategies for prevention and treatment of knee osteoarthritis.
ISSN: 0268-0033
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group for Musculoskeletal Rehabilitation
Human Movement Biomechanics Research Group
Cell and Gene Therapy Applications (-)
Skeletal Biology and Engineering Research Center (+)
× corresponding author
# (joint) last author

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