Title: Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice
Authors: De Schutter, Tim ×
Andrei, Graciela
Topalis, Dimitrios
Duraffour, Sophie
Mitera, Tania
Naesens, Lieve
van den Oord, Joost
Matthys, Patrick
Snoeck, Robert #
Issue Date: Feb-2013
Publisher: Elsevier
Series Title: Cancer Letters vol:329 issue:2 pages:137-145
Article number: 10.1016/j.canlet.2012.10.036
Abstract: Cidofovir has shown antiproliferative effects against human papillomavirus (HPV)-positive cells and successfully suppressed the growth of HPV-positive xenografts in athymic nude mice. The present study evaluated the effect of cidofovir on several disease parameters in this animal model. Intratumoral administration of cidofovir resulted in a beneficial effect on body weight gain, a reduction in splenomegaly, a partial restoration of tryptophan catabolism, and diminished the inflammatory state induced by the xenografts. Administration of cidofovir to tumor-free animals did not have a direct effect on these parameters. Beyond suppressing tumor growth, intratumoral treatment with cidofovir ameliorated the pathology associated with HPV-tumor growth.
ISSN: 0304-3835
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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