Title: Short-Term Effects of High-Dose Khat on Sperm Parameters and Reproductive Hormonal Levels in Olive Baboons (Papio anubis)
Authors: Nyachieo, Atunga ×
Kiraithe, Muthamia M
Spiessens, Carl
Chai, Daniel C
Kiulia, Nicholas M
D'Hooghe, Thomas
Mwenda, Jason M #
Issue Date: 2013
Publisher: Karger
Series Title: Gynecologic and obstetric investigation vol:75 issue:2 pages:109-114
Abstract: The biological effects of khat (Catha edulis) on reproduction and fertility are inadequately investigated and controversial, hence we determined the effects of oral administration of high-dose khat on sperm parameters and male hormonal levels in olive baboons. In this study, 6 male baboons received a high dose of khat (500 g/week) during 1 month. Electroejaculation for sperm studies (concentration, motility and chromatin integrity) and plasma collection for hormonal analysis (testosterone, prolactin and cortisol) were done weekly during 1 month before and 1 month during khat administration as well as 2 weeks after the last dose of khat administration. Administration of khat extract induced a significant reduction in sperm motility (p = 0.008), sperm count (p = 0.041), sperm chromatin integrity (p = 0.0003), testosterone levels (p = 0.035) and prolactin levels (p = 0.0115), but not in cortisol levels and sperm volume (p > 0.05). The results suggest that high-dose khat decreases sperm quality and testosterone and hence may contribute to male infertility.
ISSN: 0378-7346
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Sexual, Pelvic, Reproductive and Family Studies (-)
× corresponding author
# (joint) last author

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