Title: Non-invasive ventilation in amyotrophic lateral sclerosis
Authors: Vrijsen, Bart ×
Testelmans, Dries
Belge, Catharina
Robberecht, Wim
Van Damme, Philip
Buyse, Bertien #
Issue Date: Mar-2013
Publisher: Informa Healthcare
Series Title: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration vol:14 issue:2 pages:85-95
Article number: 10.3109/21678421.2012.745568
Abstract: Abstract Non-invasive ventilation (NIV) is widely used to improve alveolar hypoventilation in amyotrophic lateral sclerosis. Several studies indicate a better survival when NIV is used, certainly in patients with none to moderate bulbar dysfunction. Data on quality of life (QoL) are rather disputable. Overall QoL is shown to be equivalent in patients with or without NIV, although health-related QoL is shown to be increased in patients with none to moderate bulbar dysfunction. NIV improves sleep quality, although patient-ventilator asynchronies are demonstrated. FVC < 50%, seated or supine, has been widely applied as threshold to initiate NIV. Today, measurements of respiratory muscle strength, nocturnal gas exchange and symptomatic complaints are used as indicators to start NIV. Being compliant with NIV therapy increases QoL and survival. Cough augmentation has an important role in appropriate NIV. Patients have today more technical options and patients with benefit from these advances are growing in number. Tracheal ventilation needs to be discussed when NIV seems impossible or becomes insufficient.
ISSN: 2167-8421
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Neurobiology (Vesalius Research Center)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Non invasive ventilation in ALS - Amyothrophic lateral sclerosis and frontotemporal degeneration.pdf Published 114KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science