Title: Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance
Authors: Quintens, Roel
Singh, Sarvjeet
Lemaire, Katleen
De Bock, Katrien
Granvik, Mikaela
Schraenen, Anica
Vroegrijk, Irene
Costa, Veronica
Van Noten, Pieter
Lambrechts, Dennis
Lehnert, Stefan
Van Lommel, Leentje
Thorrez, Lieven
de Faudeur, Geoffroy
Romijn, Johannes
Shelton, John
Scorrano, Luca
Lijnen, Roger
Voshol, Peter
Carmeliet, Peter
Mammen, Pradeep
Schuit, Frans # ×
Issue Date: Jan-2013
Publisher: Public Library of Sciene
Series Title: PLoS One vol:8 issue:2 pages:e56719
Article number: e56719
Abstract: Oxidative phosphorylation in mitochondria is responsible for 90% of ATP synthesis in
most cells. This essential housekeeping function is mediated by nuclear and
mitochondrial genes encoding subunits of complex I to V of the respiratory chain.
Although complex IV is the best studied of these complexes, the exact function of the
striated muscle-specific subunit COX6A2 is still poorly understood. In this study, we
show that Cox6a2-deficient mice are protected against high-fat diet-induced obesity,
insulin resistance and glucose intolerance. This phenotype results from elevated
energy expenditure and a skeletal muscle fiber type switch towards more oxidative
fibers. At the molecular level we observe increased formation of reactive oxygen
species, constitutive activation of AMP-activated protein kinase, and enhanced
expression of uncoupling proteins. Our data indicate that COX6A2 is a regulator of
respiratory uncoupling in muscle and we demonstrate that a novel and direct link exists
between muscle respiratory chain activity and diet-induced obesity / insulin resistance.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gene Expression Unit
Development and Regeneration, Campus Kulak Kortrijk
Laboratory for Cytogenetics and Genome Research
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Molecular and Vascular Biology
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
Surface and Interface Engineered Materials
× corresponding author
# (joint) last author

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