Math1: an essential gene for the generation of inner ear hair cells
Bermingham, N A × Hassan, Bassem Price, S D Vollrath, M A Ben-Arie, N Eatock, R A Bellen, H J Lysakowski, A Zoghbi, H Y #
American Association for the Advancement of Science
Science vol:284 issue:5421 pages:1837-41
The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. Math1, a mouse homolog of the Drosophila proneural gene atonal, is expressed in inner ear sensory epithelia. Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells.