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Title: Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines
Authors: Sozzani, S ×
Sallusto, F
Luini, W
Zhou, D
Piemonti, L
Allavena, P
Van Damme, Jozef
Valitutti, S
Lanzavecchia, A
Mantovani, A #
Issue Date: 1995
Publisher: Amer assoc immunologists
Series Title: Journal of Immunology vol:155 issue:7 pages:3292-5
Abstract: Trafficking to tissues and then to lymph nodes is a crucial aspect of the immunobiology of dendritic cells. The present study was designed to identify molecules able to direct the migration of human blood-derived dendritic cells. fMLP (representative of formyl peptides of bacterial origin), C5a, and the C-C chemokines monocyte chemotactic protein (MCP)-3, MIP-1 alpha/LD78, and RANTES elicited chemotactic migration and a rise of intracellular free calcium in dendritic cells. In contrast, the C-X-C chemokines IL-8 and IP-10 and the C-C chemokines MCP-1 and MCP-2 were inactive as chemoattractants. Thus, dendritic cells respond to classical chemotactic signals and to a set of chemokines distinct from that active on monocytes and neutrophils. Chemoattractants are likely to contribute to localization and trafficking of dendritic cells and provide tools to recruit these cells in the design of immunization strategies.
ISSN: 0022-1767
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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