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Title: Axonal injury and regeneration in the adult brain of Drosophila
Authors: Ayaz, Derya ×
Leyssen, Maarten
Koch, Marta
Yan, Jiekun
Srahna, Mohammed
Sheeba, Vasu
Fogle, Keri J
Holmes, Todd C
Hassan, Bassem #
Issue Date: Jun-2008
Publisher: The Society for Neuroscience
Series Title: Journal of Neuroscience vol:28 issue:23 pages:6010-6021
Article number: 10.1523/JNEUROSCI.0101-08.2008
Abstract: Drosophila melanogaster is a leading genetic model system in nervous system development and disease research. Using the power of fly genetics in traumatic axonal injury research will significantly speed up the characterization of molecular processes that control axonal regeneration in the CNS. We developed a versatile and physiologically robust preparation for the long-term culture of the whole Drosophila brain. We use this method to develop a novel Drosophila model for CNS axonal injury and regeneration. We first show that, similar to mammalian CNS axons, injured adult wild-type fly CNS axons fail to regenerate, whereas adult-specific enhancement of protein kinase A activity increases the regenerative capacity of lesioned neurons. Combined, these observations suggest conservation of neuronal regeneration mechanisms after injury. We next exploit this model to explore pathways that induce robust regeneration and find that adult-specific activation of c-Jun N-terminal protein kinase signaling is sufficient for de novo CNS axonal regeneration injury, including the growth of new axons past the lesion site and into the normal target area.
URI: 
ISSN: 0270-6474
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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