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Title: Human biodistribution and dosimetry of (18)F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging
Authors: Van Laere, Koen ×
Ahmad, Rawaha
Hudyana, Hendra
Celen, Sofie
Dubois, Kristof
Schmidt, Mark E
Bormans, Guy
Koole, Michel #
Issue Date: Jan-2013
Series Title: European Journal of Nuclear Medicine and Molecular Imaging vol:40 issue:2 pages:254-61
Article number: 10.1007/s00259-012-2270-1
Abstract: Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP-hydrolysing enzyme with a central role in striatal signalling and implicated in neuropsychiatric disorders such as Huntington's disease, Parkinson's disease, schizophrenia and addiction. We have developed a novel PDE10A PET ligand, (18)F-JNJ42259152, and describe here its human dynamic biodistribution, safety and dosimetry.
URI: 
ISSN: 1619-7070
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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