European multicentre database of healthy controls for [(123)I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis
Varrone, Andrea × Dickson, John C Tossici-Bolt, Livia Sera, Terez Asenbaum, Susanne Booij, Jan Kapucu, Ozlem L Kluge, Andreas Knudsen, Gitte M Koulibaly, Pierre Malick Nobili, Flavio Pagani, Marco Sabri, Osama Vander Borght, Thierry Van Laere, Koen Tatsch, Klaus #
European Journal of Nuclear Medicine and Molecular Imaging vol:40 issue:2 pages:213-27
Dopamine transporter (DAT) imaging with [(123)I]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [(123)I]FP-CIT SPECT scans in healthy controls.