Title: Copper-Catalyzed Direct Secondary and Tertiary C-H Alkylation of Azoles through a Heteroarene-Amine-Aldehyde/Ketone Coupling Reaction
Authors: Vachhani, Dipakkumar
Sharma, Abhishek
Van der Eycken, Erik # ×
Issue Date: Feb-2013
Publisher: Wiley-VCH
Series Title: Angewandte Chemie - International Edition vol:52 issue:9 pages:2547-2550
Article number: 10.1002/anie.201209312
Abstract: Coupling the strangers: A copper-catalyzed three-component heteroarene-amine-aldehyde/ketone coupling affords a novel approach to the hitherto difficult direct secondary/tertiary CH alkylation of azoles. This simple method allows the facile installation of diversely substituted, branched and nitrogen-containing alkyl or alkaloid side chains on the azole moiety using readily available starting materials.
ISSN: 1433-7851
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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