Title: Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages
Authors: Sica, A ×
Saccani, A
Bottazzi, B
Polentarutti, N
Vecchi, A
Van Damme, Jozef
Mantovani, A #
Issue Date: 2000
Publisher: Amer assoc immunologists
Series Title: Journal of Immunology vol:164 issue:2 pages:762-7
Abstract: IL-12 is a central cytokine in the activation of inflammation and immunity and in the generation of Th1-type responses. Tumor-associated macrophages (TAM) from mouse and human tumors showed defective production of IL-12. Defective IL-12 production was associated with lack of p50/p65 NF-kappa B activation. TAM produced increased amounts of the immunosuppressive cytokine IL-10, Abs against IL-10 restored the defective capacity of TAM to produce IL-12, Our data suggest that during tumor growth an IL-10-dependent pathway of diversion of macrophage function can be activated into the tumor microenvironment and results in the promotion of the IL-10(+) IL-12(-) phenotype of TAM, Blocking IL-10, as well as other immunosuppressive cytokines present in the tumor microenvironment, such as TGF-beta, may complement therapeutic strategies aimed at activating type I antitumor immune responses.
ISSN: 0022-1767
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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