Title: Functional divergence of gene duplicates through ectopic recombination
Authors: Christiaens, Joaquin
Van Mulders, S.
Duitama, J.
Brown, C.A.
Ghequire, Maarten
De Meester, Luc
Michiels, Jan
Wenseleers, Tom
Voordeckers, Karin
Verstrepen, Kevin # ×
Issue Date: Nov-2012
Publisher: Published for EMBO by Oxford University Press
Series Title: EMBO Reports vol:13 issue:12 pages:1145-1151
Article number: 10.1038/embor.2012.157
Abstract: Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell-surface genes shows that chimaeric FLO alleles confer different adhesion phenotypes than the parental genes. Our results indicate that intergenic recombination between paralogs can generate a large set of new alleles, thereby providing the raw material for evolutionary adaptation and innovation.
ISSN: 1469-221X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
× corresponding author
# (joint) last author

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