Title: Carboxypeptidase M in apoptosis, adipogenesis and cancer
Authors: Denis, Catherine J ×
Deiteren, Kathleen
Hendriks, Dirk
Proost, Paul
Lambeir, Anne-Marie #
Issue Date: Feb-2013
Publisher: Elsevier Scientific Pub. Co.
Series Title: Clinica Chimica Acta vol:415 pages:306-16
Article number: 10.1016/j.cca.2012.11.012
Abstract: This review covers carboxypeptidase M (CPM) research that appeared in the literature since 2009. The focus is on aspects that are new or interesting from a clinical perspective. Available research tools are discussed as well as their pitfalls and limitations. Evidence is provided to suggest the potential involvement of CPM in apoptosis, adipogenesis and cancer. This evidence derives from the expression pattern of CPM and its putative substrates in cells and tissues. In recent years CPM emerged as a potential cancer biomarker, in well differentiated liposarcoma where the CPM gene is co-amplified with the oncogene MDM2; and in lung adenocarcinoma where coexpression with EGFR correlates with poor prognosis. The available data call for extended investigation of the function of CPM in tumor cells, tumor-associated macrophages, stromal cells and tumor neovascularisation. Such experiments could be instrumental to validate CPM as a therapeutic target.
ISSN: 0009-8981
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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