This paper holds an evolutionary approach to musical semantics. Revolving around the nature/nurture dichotomy, it considers the role of the dispositional machinery to respond to sounding stimuli. Conceiving of music as organized sound, it stresses the dynamic tension between music as a collection of vibrational events and their potential of being structured. This structuring, however, is not gratuitous. It depends on levels of processing that rely on evolutionary older levels of reacting to the sounds as well as higher-level functions of the brain, which allow listeners to emancipate themselves from mere acoustic processing of sounds to the level of epistemic interactions with the sounding music. These interactions are partly autonomous and partly constrained, but theu all stress the realization of systemic cognition in the context of a living system‘s interactions with the environment. As such, listeners can be conceived as adaptive devices, which can build up new semiotic linkages with the sounding world.