Title: Synthesis and evaluation of novel 4-substituted styryl quinazolines as potential antimicrobial agents
Authors: Modh, Rahul P ×
Patel, Amit C
Mahajan, Dharmesh H
Pannecouque, Christophe
De Clercq, Erik
Chikhalia, Kishor H #
Issue Date: Dec-2012
Publisher: VCH Verlagsgesellschaft mbH
Series Title: Archiv der Pharmazie vol:345 issue:12 pages:964-972
Article number: 10.1002/ardp.201200291
Abstract: In an attempt to afford possible antibacterial and anti-human immunodeficiency virus (HIV) agents, a series of 22 novel styryl quinazoline-based heterocyclic entities were designed and synthesized. Various substituted aryl urea and thiourea cores were incorporated at position 4 of quinazoline, followed by styrylation of position 2, aiming at an augmented biological potential. The synthesized compounds were well characterized through IR, (1) H NMR, (13) C NMR and elemental analyses. All compounds were screened for their in vitro anti-HIV activity against the HIV-1 (IIIB) and HIV-2 (ROD) strains. The antibacterial activity was also evaluated against various pathogenic Gram-positive and Gram-negative bacterial strains.
ISSN: 0365-6233
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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