Title: Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region
Authors: Iscru, Emilia ×
Ahmed, Tariq
Coremans, Vanessa
Bozzi, Y.
Caleo, M.
Conway, Ed
D'Hooge, Rudi
Balschun, Detlef #
Issue Date: Feb-2013
Publisher: Pergamon Press
Series Title: Neuroscience vol:231 pages:413-419
Article number: 10.1016/j.neuroscience.2012.10.049
Abstract: In adult mammals, newborn neural precursor cells (NPCs) derived from either the subventricular zone (SVZ) or the subgranular zone (SGZ) migrate into the olfactory bulb and the dentate gyrus (DG), respectively, where some of them mature into excitatory and inhibitory neurons. There is increasing evidence that this neurogenesis process is important for some types of learning and synaptic plasticity and vice versa. Survivin, a member of the inhibitor-of-apoptosis protein (IAP) family, has been suggested to have a central role in the regulation of neurogenesis. The protein is abundantly expressed in nervous tissue during embryonic development while being restricted postnatally to proliferating and migrating NPCs in SVZ and SGZ. Here we examined adult Survivin(Camcre) mice with a conditional deletion of the survivin gene in embryonic neurogenic regions. Although the deletion of survivin had no effect on basic excitability in DG and CA1-region, there was a marked impairment of long-term potentiation (LTP) in these areas. Our data support a function of survivin in hippocampal synaptic plasticity and learning and underline the importance of adult brain neurogenesis for proper operation of the hippocampal tri-synaptic circuit and the physiological functions that depend on it.
ISSN: 0306-4522
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
Vesalius Research Centre (-)
× corresponding author
# (joint) last author

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