Title: Adhesion molecules and IL-1 costimulate T lymphocytes in the autologous MECLR in psoriasis
Authors: Prens, E ×
't Hooft-Benne, K
Tank, B
Van Damme, Jozef
van Joost, T
Benner, R #
Issue Date: 1996
Publisher: Springer verlag
Series Title: Archives of dermatological research vol:288 issue:2 pages:68-73
Abstract: Membrane molecules such as CD36 (OKM5), intercellular adhesion molecule-1 (ICAM-1, CD54), gamma interferon-induced protein 10 (gamma-IP10) and IL-1 are induced and/or upregulated in psoriatic epidermis, These molecules have important accessory, trafficking or signalling functions in the immune system and also play a role in the pathophysiology of psoriasis, The relevance of adhesion molecules, CD36 and epidermal IL-1 in psoriasis was studied in vitro in the autologous mixed epidermal cell- T lymphocyte reaction (MECLR), Their level of expression was quantitated in epidermal cell suspensions (ECS) from patients with psoriasis and their function was assessed by blocking with specific mAbs and antisera or by depleting CD36(+) cells from the ECS prior to the MECLR, ECS from psoriatic lesions contained increased numbers of CD36(+) (23 +/- 12%), ICAM-1 (31 +/- 14%) and IL-1(+) (57 +/- 21%) cells, The autologous MECLR was inhibited in samples from all patients by mAb to CD2 (LFA-2), CD11a (LFA-1 alpha), CD18 (LFA-1 beta), ICAM-1, CD58 (LFA-3) and an antiserum to IL-1 beta, Thus, adhesion molecules facilitate inflammation in psoriasis not only via adhesion and recruitment of T lymphocyte in psoriatic lesions, but also via activation of T cells. Furthermore CD36 molecules on psoriatic epidermal cells do not costimulate autologous T lymphocytes in psoriasis, The observed costimulatory function of IL-1 beta in the MECLR emphasizes its relevance in psoriasis.
ISSN: 0340-3696
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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