Title: Novel carbocyclic nucleosides containing a cyclobutyl ring. Guanosine and adenosine analogues
Authors: Borges, JER ×
Fernandez, F
Garcia, X
Hergueta, AR
Lopez, C
Andrei, Graciela
Snoeck, Robert
Witvrouw, Myriam
Balzarini, Jan
De Clercq, Erik #
Issue Date: Jul-1998
Publisher: M. Dekker
Series Title: Nucleosides & nucleotides vol:17 pages:1237-1253
Abstract: (1R,cis)-2-(3-Amino-2,2-dimethylcyclobutyl)ethanol (4) was used as a precursor in the synthesis of cyclobutyl nucleoside analogues containing guanine, 8-azaguanine, adenine or 8-azaadenine. All the compounds were evaluated as antiviral agents in a variety of assay systems. Some activity was noted for compound 13, 17, 19 and 20 against vaccinia virus and for compounds 11, 12, 13, 17, 19 and 20 against herpes simplex virus, at concentrations that were up to 10-fold below the cytotoxic concentrations for the host cells.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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