Title: Antiviral portrait series: 4. Polysulfates as inhibitors of HIV and other enveloped viruses
Authors: Witvrouw, Myriam ×
Desmyter, J
De Clercq, Erik #
Issue Date: 1994
Series Title: Antivir Chem Chemoth vol:5 pages:345-359
Abstract: Polysulfates are highly potent and selective inhibitors of the in vitro replication of HIV and other enveloped viruses. They not only inhibit the cytopathic effect of HIV, but also prevent HIV-induced syncytium (giant cell) formation. They also act synergistically with other anti-HIV drugs. The anti-HIV activity of polysulfates is a result of their shielding of the positively charged sites in the V3 loop of the viral envelope glycoprotein gp120. When polysulfates were administered intravenously to rabbits, their half-life was approximately 2 h. Although they are very poorly absorbed following oral administration, they can be made orally bioavailable with the appropriate chemical modifications. Also, polysulfates may lose (much of) their anticoagulant activity upon chemical modification without giving up their anti-HIV activity. Their efficacy in the therapy and/or prophylaxis of retroviral infections remains to be demonstrated both in animal models and in humans.
ISSN: 0956-3202
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Antiviral Chem Chemother5(1994).pdfMain article Published 2978KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science