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Title: Local delivery of small and large biomolecules in craniomaxillofacial bone
Authors: Ji, Wei
Wang, Huanan
van den Beucken, Jeroen J J P
Yang, Fang
Walboomers, X Frank
Leeuwenburgh, Sander
Jansen, John A # ×
Issue Date: Sep-2012
Publisher: Elsevier Science Publishers, B.V.
Series Title: Advanced Drug Delivery Reviews vol:64 issue:12 pages:1152-1164
Article number: 10.1016/j.addr.2012.03.003
Abstract: Current state of the art reconstruction of bony defects in the craniomaxillofacial (CMF) area involves transplantation of autogenous or allogenous bone grafts. However, the inherent drawbacks of this approach strongly urge clinicians and researchers to explore alternative treatment options. Currently, a wide interest exists in local delivery of biomolecules from synthetic biomaterials for CMF bone regeneration, in which small biomolecules are rapidly emerging in recent years as an interesting adjunct for upgrading the clinical treatment of CMF bone regeneration under compromised healing conditions. This review highlights recent advances in the local delivery small and large biomolecules for the clinical treatment of CMF bone defects. Further, it provides a perspective on the efficacy of biomolecule delivery in CMF bone regeneration by reviewing presently available reports of pre-clinical studies using various animal models.
URI: 
ISSN: 0169-409X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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