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Title: Targeted Therapy with Rituximab in Felty's Syndrome: A Case Report
Authors: Heylen, Line ×
Dierickx, Daan
Vandenberghe, Peter
Westhovens, Rene #
Issue Date: Dec-2012
Publisher: Bentham Science Publishers
Series Title: The Open Rheumatology Journal vol:6 pages:312-4
Article number: 10.2174/1874312901206010312
Abstract: Felty's syndrome is a rare, severe extra-articular manifestation of rheumatoid arthritis (RA). There is no standard therapy, and several disease-modifying antirheumatic drugs have been used with varying success. Only very few reports exist in literature on the use of biologicals in this indication and this with a variable efficacy. We report the case of a 53-year-old woman with severe refractory/partly undertreated RA who presented with Felty's syndrome and pancytopenia, in whom treatment with rituximab led to an marked increase of red blood cells, neutrophils and thrombocytes. In addition, the RA disease activity status improved dramatically and treatment with steroids could be reduced. The current sparse literature on this topic is reviewed.
ISSN: 1874-3129
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Neuro-musculo-skeletal Research (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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