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Title: Placental Mitochondrial DNA Content and Particulate Air Pollution during in Utero Life
Authors: Janssen, Bram G
Munters, Elke
Pieters, Nicky
Smeets, Karen
Cox, Bianca
Cuypers, Ann
Fierens, Frans
Penders, Joris
Vangronsveld, Jaco
Gyselaers, Wilfried
Nawrot, Tim S # ×
Issue Date: Sep-2012
Publisher: U.S. Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Environmental Health Sciences
Series Title: Environmental Health Perspectives vol:120 issue:9 pages:1346-1352
Abstract: Background: Studies emphasize the importance of particulate matter (PM) in the formation of reactive oxygen species and inflammation. We hypothesized that these processes can influence mitochondrial function of the placenta and fetus.Objective: We investigated the influence of PM10 exposure during pregnancy on the mitochondrial DNA content (mtDNA content) of the placenta and umbilical cord blood.Methods: DNA was extracted from placental tissue (n = 174) and umbilical cord leukocytes (n = 176). Relative mtDNA copy numbers (i.e., mtDNA content) were determined by real-time polymerase chain reaction. Multiple regression models were used to link mtDNA content and in utero exposure to PM10 over various time windows during pregnancy.Results: In multivariate-adjusted analysis, a 10-µg/m³ increase in PM10 exposure during the last month of pregnancy was associated with a 16.1% decrease [95% confidence interval (CI): -25.2, -6.0%, p = 0.003] in placental mtDNA content. The corresponding effect size for average PM10 exposure during the third trimester was 17.4% (95% CI: -31.8, -0.1%, p = 0.05). Furthermore, we found that each doubling in residential distance to major roads was associated with an increase in placental mtDNA content of 4.0% (95% CI: 0.4, 7.8%, p = 0.03). No association was found between cord blood mtDNA content and PM10 exposure.Conclusions: Prenatal PM10 exposure was associated with placental mitochondrial alterations, which may both reflect and intensify oxidative stress production. The potential health consequences of decreased placental mtDNA content in early life must be further elucidated.
ISSN: 0091-6765
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Occupational, Environmental and Insurance Medicine (-)
× corresponding author
# (joint) last author

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