Title: Endocrine-disrupting chemicals in human follicular fluid impair in vitro oocyte developmental competence
Authors: Petro, Evi M L ×
Leroy, Jo L M R
Covaci, Adrian
Fransen, Erik
De Neubourg, Diane
Dirtu, Alin C
De Pauw, Ingrid
Bols, Peter E J #
Issue Date: Apr-2012
Publisher: Published for the European Society of Human Reproduction and Embryology by IRL Press
Series Title: Human Reproduction vol:27 issue:4 pages:1025-1033
Abstract: Increased global industrial activity has exposed humans to a wide variety of chemical substances some of which, called 'endocrine-disrupting chemicals' (EDCs) or 'endocrine disruptors', can disrupt the endocrine system in the body. The ovarian follicle is a very fragile micro-environment where interactions between hormones, growth factors, the oocyte and its surrounding somatic cells are essential to generate a fully competent oocyte. In vitro experiments suggest that EDCs can disturb this finely tuned balance, but very scarse in vivo data are available to confirm this assumption. Therefore, we have investigated if the presence of EDCs in human follicular fluid is a risk factor for the developmental competence of an in vivo exposed oocyte. Furthermore, because of the limited access to human follicular fluid, we verified if follicular fluid contamination can be predicted based on EDC levels in serum.
ISSN: 0268-1161
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Sexual, Pelvic, Reproductive and Family Studies (-)
× corresponding author
# (joint) last author

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