Plasma concentrations of the vitamin E-binding protein afamin are associated with overall and progression-free survival and platinum sensitivity in serous ovarian cancer- a study by the OVCAD consortium
Melmer, Andreas × Fineder, Linda Lamina, Claudia Kollerits, Barbara Dieplinger, Benjamin Braicu, Ioana Sehouli, Jalid Cadron, Isabelle Mahner, Sven Zeimet, Alain G Castillo-Tong, Dan Cacsire Ebenbichler, Christoph F Zeillinger, Robert Dieplinger, Hans #
Gynecologic Oncology vol:128 issue:1 pages:38-43
Comparative proteomics identified the plasma protein afamin as potential biomarker for ovarian cancer (OC). Significantly decreased afamin plasma concentrations in pre-therapeutic OC patients reconstituted to control values after successful tumor surgery. This study evaluates the association of afamin with survival and response to therapy in serous OC patients within the OVCAD consortium project.