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Title: twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development
Authors: Czerny, T *
Halder, Georg *
Kloter, U
Souabni, A
Gehring, W J
Busslinger, M # ×
Issue Date: Mar-1999
Publisher: Cell Press
Series Title: Molecular Cell vol:3 issue:3 pages:297-307
Abstract: The Drosophila Pax-6 gene eyeless (ey) plays a key role in eye development. Here we show tht Drosophila contains a second Pax-6 gene, twin of eyeless (toy), due to a duplication during insect evolution. Toy is more similar to vertebrate Pax-6 proteins than Ey with regard to overall sequence conservation, DNA-binding function, and early expression in the embryo, toy and ey share a similar expression pattern in the developing visual system, and targeted expression of Toy, like Ey, induces the formation of ectopic eyes. Genetic and biochemical evidence indicates, however, that Toy functions upstream of ey by directly regulating the eye-specific enhancer of ey. Toy is therefore required for initiation of ey expression in the embryo and acts through Ey to activate the eye developmental program.
URI: 
ISSN: 1097-2765
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
* (joint) first author
× corresponding author
# (joint) last author

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