Title: Low frequency of epigenetic events in urothelial tumors in young patients
Authors: Owen, Helen ×
Giedl, J
Wild, Peter J
Fine, Samson W
Humphrey, Peter A
Dehner, Louis P
Amin, Mahul B
Epstein, Johnathan I
Blaszyk, H
Hughes, David
Hartmann, Arndt
Stoehr, Robert
Catto, James W #
Issue Date: Aug-2010
Publisher: Elsevier Science Inc.
Series Title: Journal of Urology vol:184 issue:2 pages:459-63
Abstract: Bladder urothelial cell carcinoma is uncommon in young patients. We recently reported a series of tumors in patients younger than 20 years at diagnosis and performed exhaustive genetic screening for molecular alterations. Few events typical of bladder urothelial cell carcinoma were detected. Since many carcinogenic events occur at the epigenetic rather than the genetic level, we analyzed the same tumors for alterations in DNA hypermethylation. We compared our findings with those in tumors in older patients with similar pathological profiles.
ISSN: 0022-5347
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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