Low frequency of epigenetic events in urothelial tumors in young patients
Owen, Helen × Giedl, J Wild, Peter J Fine, Samson W Humphrey, Peter A Dehner, Louis P Amin, Mahul B Epstein, Johnathan I Blaszyk, H Hughes, David Hartmann, Arndt Stoehr, Robert Catto, James W #
Elsevier Science Inc.
Journal of Urology vol:184 issue:2 pages:459-63
Bladder urothelial cell carcinoma is uncommon in young patients. We recently reported a series of tumors in patients younger than 20 years at diagnosis and performed exhaustive genetic screening for molecular alterations. Few events typical of bladder urothelial cell carcinoma were detected. Since many carcinogenic events occur at the epigenetic rather than the genetic level, we analyzed the same tumors for alterations in DNA hypermethylation. We compared our findings with those in tumors in older patients with similar pathological profiles.