Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities
Sipos, Attila × Máté, Gábor Rőth, Erzsébet Borbás, Anikó Batta, Gyula Bereczki, Ilona Kéki, Sándor Jóna, István Ostorházi, Eszter Rozgonyi, Ferenc Vanderlinden, Evelien Naesens, Lieve Herczegh, Pál #
European Journal of Medicinal Chemistry vol:58 pages:361-367
Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.