Title: Specific inhibition of epithelial Na+ channels by antisense oligonucleotides for the treatment of Na+ hyperabsorption in cystic fibrosis
Authors: Sobczak, Katja ×
Segal Stanciu, Andrei
Bangel-Ruland, Nadine
Semmler, Judith
Van Driessche, Willy
Lindemann, Hermann
Heermann, Ralf
Weber, Wolf-Michael #
Issue Date: Sep-2009
Publisher: John Wiley & Sons
Series Title: The Journal of Gene Medicine vol:11 issue:9 pages:813-23
Abstract: Cystic fibrosis (CF) respiratory epithelia are characterized by a defect Cl(-) secretion and an increased Na(+) absorption through epithelial Na(+) channels (ENaC). The present study aimed to find an effective inhibitor of human ENaC with respect to replacing amiloride therapy for CF patients. Therefore, we developed specific antisense oligonucleotides (AON) that efficiently suppress Na(+) hyperabsorption by inhibiting the expression of the alpha-ENaC subunit.
ISSN: 1099-498X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Ion Channel Research
× corresponding author
# (joint) last author

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