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Title: Research needs in allergy: an EAACI position paper, in collaboration with EFA
Authors: Papadopoulos, Nikolaos G ×
Agache, Ioana
Bavbek, Sevim
Bilo, Beatrice M
Braido, Fulvio
Cardona, Victoria
Custovic, Adnan
Demonchy, Jan
Demoly, Pascal
Eigenmann, Philippe
Gayraud, Jacques
Grattan, Clive
Heffler, Enrico
Hellings, Peter W
Jutel, Marek
Knol, Edward
Lötvall, Jan
Muraro, Antonella
Poulsen, Lars K
Roberts, Graham
Schmid-Grendelmeier, Peter
Skevaki, Chrysanthi
Triggiani, Massimo
Vanree, Ronald
Werfel, Thomas
Flood, Breda
Palkonen, Susanna
Savli, Roberta
Allegri, Pia
Annesi-Maesano, Isabella
Annunziato, Francesco
Antolin-Amerigo, Dario
Apfelbacher, Christian
Blanca, Miguel
Bogacka, Ewa
Bonadonna, Patrizia
Bonini, Matteo
Boyman, Onur
Brockow, Knut
Burney, Peter
Buters, Jeroen
Butiene, Indre
Calderon, Moises
Cardell, Lars Olaf
Caubet, Jean-Christoph
Celenk, Sevcan
Cichocka-Jarosz, Ewa
Cingi, Cemal
Couto, Mariana
Dejong, Nicolette
Del Giacco, Stefano
Douladiris, Nikolaos
Fassio, Filippo
Fauquert, Jean-Luc
Fernandez, Javier
Rivas, Montserrat Fernandez
Ferrer, Marta
Flohr, Carsten
Gardner, James
Genuneit, Jon
Gevaert, Philippe
Groblewska, Anna
Hamelmann, Eckard
Hoffmann, Hans Jürgen
Hoffmann-Sommergruber, Karin
Hovhannisyan, Lilit
Hox, Valérie
Jahnsen, Frode L
Kalayci, Omer
Kalpaklioglu, Ayse Füsun
Kleine-Tebbe, Jörg
Konstantinou, George
Kurowski, Marcin
Lau, Susanne
Lauener, Roger
Lauerma, Antti
Logan, Kirsty
Magnan, Antoine
Makowska, Joanna
Makrinioti, Heidi
Mangina, Paraskevi
Manole, Felicia
Mari, Adriano
Mazon, Angel
Mills, Clare
Mingomataj, Ervin C
Niggemann, Bodo
Nilsson, Gunnar
Ollert, Markus
O'Mahony, Liam
O'Neil, Serena
Pala, Gianni
Papi, Alberto
Passalacqua, Gianni
Perkin, Michael
Pfaar, Oliver
Pitsios, Constantinos
Quirce, Santiago
Raap, Ulrike
Raulf-Heimsoth, Monika
Rhyner, Claudio
Robson-Ansley, Paula
Alves, Rodrigo Rodrigues
Roje, Zeljka
Rondon, Carmen
Rudzeviciene, Odilija
Ruëff, Franziska
Rukhadze, Maia
Rumi, Gabriele
Sackesen, Cansin
Santos, Alexandra F
Santucci, Annalisa
Scharf, Christian
Schmidt-Weber, Carsten
Schnyder, Benno
Schwarze, Jürgen
Senna, Gianenrico
Sergejeva, Svetlana
Seys, Sven
Siracusa, Andrea
Skypala, Isabel
Sokolowska, Milena
Spertini, Francois
Spiewak, Radoslaw
Sprikkelman, Aline
Sturm, Gunter
Swoboda, Ines
Terreehorst, Ingrid
Toskala, Elina
Traidl-Hoffmann, Claudia
Venter, Carina
Vlieg-Boerstra, Berber
Whitacker, Paul
Worm, Margitta
Xepapadaki, Paraskevi
Akdis, Cezmi A #
Issue Date: Nov-2012
Publisher: European Academy of Allergy and Clinical Immunology
Series Title: Clinical and Translational Allergy vol:2 issue:1 pages:21
Abstract: ABSTRACT: In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.
URI: 
ISSN: 2045-7022
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical Immunology
× corresponding author
# (joint) last author

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