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Title: In search of Broad Applicable, Small Molecule Inhibitors of Salmonella Biofilm Formation
Authors: Robijns, Stijn
Steenackers, Hans
Janssens, Joost
Chaltin, Patrick
Levin, Jeremy
De Vos, Dirk
Vanderleyden, Jos
De Keersmaecker, Sigrid #
Issue Date: Apr-2009
Conference: Young microbiologists symposium: microbe signalling, organisation and pathogenesis location:University College Cork Ireland date:21-22 April 2009
Abstract: Salmonella is one of the most important causes of foodborne infections worldwide. A major difficulty in the battle against Salmonella is the fact that Salmonella can form biofilms on various biotic and abiotic surfaces. Biofilms are multicellular structures, in which the bacteria live in a self-produced gel-like matrix. Within these biofilms, Salmonella is protected against a wide range of environmental influences such as desiccation, antibiotics, disinfectants and the immune system. As such, biofilm formation is an important survival strategy of Salmonella, both in- and outside the host. Therefore, the prevention or eradication of these biofilms could be an effective way to limit the spread of Salmonella.
Our laboratory has identified a potent group of Salmonella biofilm inhibitors, namely the brominated furanones. Even though they are very potent molecules, they only seem to be active at temperatures below 25 °C. Therefore, we are currently conducting a screening of a compound library, consisting of 17.000 small molecules, in search for Salmonella biofilm inhibitors which are active at a temperature ranging from 16 °C till 37 °C, and therefore have potential to be used both in- and outside the host. The library contains a broad range of compounds, selected on their possible drug ability according to the Lipinski Rule of Five.
We aim at identifying compounds that inhibit biofilm formation, but that do not kill the bacteria. In this way, the development of resistance, which is a major drawback of classical antibiotics, is less likely. As such, these biofilm inhibitors could be a sustainable alternative in the production of safe and healthy food.
Description: Poster
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Departement Sociaal-agogisch Werk - IPSOC KATHO
Centre for Surface Chemistry and Catalysis
Intellectual Property
Centre of Microbial and Plant Genetics
# (joint) last author

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