Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog
Bourgonje, Vincent J A × Schoenmakers, Marieke Beekman, Jet D M van der Nagel, Roel Houtman, Marien J C Miedema, Lars F Antoons, Gudrun Sipido, Karin de Windt, Leon J van Veen, Toon A B Vos, Marc A #
Heart Rhythm vol:9 issue:11 pages:1875-1883.e2
The calcium-dependent signaling molecules calcineurin and calcium/calmodulin-dependent protein kinase II (CaMKII) both have been linked to decompensated hypertrophy and arrhythmias. CaMKII is also believed to be involved in acute modulation of ion channels.