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Title: Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities
Authors: Sipos, Attila ×
Török, Zsolt
Rőth, Erzsébet
Kiss-Szikszai, Attila
Batta, Gyula
Bereczki, Ilona
Fejes, Zsolt
Borbás, Anikó
Ostorházi, Eszter
Rozgonyi, Ferenc
Naesens, Lieve
Herczegh, Pál #
Issue Date: Dec-2012
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:22 issue:23 pages:7092-7096
Article number: 10.1016/j.bmcl.2012.09.079
Abstract: The primary amino function of teicoplanin pseudoaglycon has been transformed into arylthioisoindole or benzoisoindole and glycosylthioisoindole derivatives, in a reaction with o-phthalaldehyde or naphtalene-2,3-dicarbaldehyde and various thiols. All of the obtained semisynthetic antibiotics exhibited potent antibacterial activities against Gram-positive bacteria in the ng per ml concentration range. A few of them showed antiviral activity, in particular against influenza virus.
URI: 
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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