N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy
Håkansson, Joakim × Ståhlberg, Anders Wolfhagen Sand, Fredrik Gerhardt, Holger Semb, Henrik #
Public Library of Sciene
PLoS One vol:6 issue:10
Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia. The underlying mechanism for epiretinal neovascularization (tuft formation), which contributes to blindness, has yet to be identified. Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis.