Title: Vasopressin/Oxytocin-related signaling regulates gustatory associative learning in C. elegans
Authors: Beets, Isabel
Janssen, Tom
Meelkop, Ellen
Temmerman, Liesbet
Suetens, Nick
Rademakers, Suzanne
Jansen, Gert
Schoofs, Liliane # ×
Issue Date: 26-Oct-2012
Publisher: American Association for the Advancement of Science
Series Title: Science vol:338 issue:6106 pages:543-545
Abstract: Vasopressin- and oxytocin-related neuropeptides are key regulators of animal physiology, including water balance and reproduction. Although these neuropeptides also modulate social behavior and cognition in mammals, the mechanism for influencing behavioral plasticity and the evolutionary origin of these effects are not well understood. Here, we present a functional vasopressin- and oxytocin-like signaling system in the nematode Caenorhabditis elegans. Through activation of its receptor NTR-1, a vasopressin/oxytocin-related neuropeptide, designated nematocin, facilitates the experience-driven modulation of salt chemotaxis, a type of gustatory associative learning in C. elegans. Our study suggests that vasopressin and oxytocin neuropeptides have ancient roles in modulating sensory processing in neural circuits that underlie behavioral plasticity.
ISSN: 0036-8075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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