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Title: Bisphosphonates: prevention of bone metastases in lung cancer
Authors: Decoster, Lynn ×
de Marinis, Filippo
Syrigos, Kostas
Hirsh, Vera
Nackaerts, Kristiaan #
Issue Date: 2012
Publisher: Springer-Verlag
Series Title: Recent Results in Cancer Research vol:192 pages:93-108
Abstract: In patients with lung cancer, bone is one of the most frequent sites of distant spread, with approximately 30% of patients developing skeletal metastases. About half of these patients will experience a skeletal-related event, the occurrence of which not only affects quality of life, but is also associated with poor prognosis. Bisphosphonates are currently the mainstay for treating bone metastases in patients with lung cancer, with proven beneficial effects on prevention and delay of skeletal complications. Their role in preventing the development of skeletal metastases, their anti-tumoral properties and their effect on survival remain to be elucidated. Other bone-targeted therapies are being investigated in phase II and III clinical trials and might expand the therapeutic arsenal in the near future.
ISSN: 0080-0015
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
× corresponding author
# (joint) last author

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