Title: Ascorbic Acid Has Superior Ex Vivo Antiproliferative, Cell Death-Inducing and Immunomodulatory Effects over IFN-alpha in HTLV-1-Associated Myelopathy
Authors: Moens, Britta ×
Decanine, Daniele
Menezes, Soraya
Khouri, Ricardo
Silva-Santos, Gilvaneia
Lopez, Giovanni
Alvarez, Carolina
Talledo, Michael
Gotuzzo, Eduardo
Kruschewsky, Ramon de Almeida
Galvao-Castro, Bernardo
Vandamme, Anne-Mieke
Van Weyenbergh, Johan #
Issue Date: Jul-2012
Publisher: Public Library Science
Series Title: PLoS Neglected Tropical Diseases vol:6 issue:7 pages:e1729
Article number: doi:10.1371/journal.pntd.0001729
Abstract: Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) monotherapy in a large open clinical trial. However, there is a lack of in vivo and in vitro studies exploring and comparing the effects of high-dose AA and IFN-α treatment in the context of HAM/TSP. Therefore, we performed the first comparative analysis of the ex vivo and in vitro molecular and cellular mechanisms of action of IFN-α and high-dose AA in HAM/TSP.
ISSN: 1935-2735
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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