Author:

Keywords:

Actins, Adult, Aged, Antigens, CD31, Cell Movement, Cell Proliferation, Cells, Cultured, Chronic Disease, Desmin, Endothelium, Vascular, Female, Humans, Hypertension, Pulmonary, Male, Middle Aged, Muscle, Smooth, Vascular, Pulmonary Artery, Pulmonary Embolism, Smooth Muscle Myosins, von Willebrand Factor, chronic thromboembolic pulmonary hypertension, Science & Technology, Life Sciences & Biomedicine, Respiratory System, Chronic Thromboembolic Pulmonary Hypertension, Smooth Muscle Cells, Endothelial cells, Vascular Remodeling, ENDOTHELIAL-CELLS, PROGENITOR CELLS, RISK-FACTORS, THROMBOENDARTERECTOMY, DIFFERENTIATION, TISSUE, Platelet Endothelial Cell Adhesion Molecule-1, 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 3201 Cardiovascular medicine and haematology, 3202 Clinical sciences

Abstract:

Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is associated with proximal pulmonary artery obstruction and vascular remodeling. We hypothesized that pulmonary arterial smooth muscle (PASMC) and endothelial cells (PAEC) may actively contribute to remodeling of the proximal pulmonary vascular wall in CTEPH. Our present objective was to characterize PASMC and PAEC from large arteries of CTEPH patients and investigate their potential involvement in vascular remodeling.