Title: Late vitamin K deficiency bleeding leading to a diagnosis of cystic fibrosis: a case report
Authors: Ngo, B ×
Van Pelt, K
Labarque, Veerle
Van De Casseye, W
Penders, J #
Issue Date: Mar-2011
Publisher: Acta clinica belgica
Series Title: Acta Clinica Belgica vol:66 issue:2 pages:142-3
Abstract: Vitamin K deficiency bleeding (VKDB) in infants still occurs despite worldwide use of prophylaxis. Clinical manifestations can be dramatic with over 50% of patients presenting with intracranial haemorrhage and a mortality rate of 20% in late vitamin K deficiency bleeding. Special attention should be given to infants with a high risk profile (preterm, breast feeding, cholestasis, malabsorption). A tentative diagnosis can be made observing quick normalisation of some easy-to-perform haemostatic parameters (PT, aPTT) after administration of vitamin K. Nowadays, VKDB can still be the first clinical sign of diseases causing malabsorption of fat-soluble vitamins. In this case report, VKDB led to the diagnosis of cystic fibrosis, the most common fatal autosomal recessive disease among Caucasian people.
ISSN: 1784-3286
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
× corresponding author
# (joint) last author

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